775 Structural and molecular similarities between plantar and wound keratinocytes - is the foot a chronic wound?

Plantar skin is known for specializations such as lack of hair, accelerated epidermal turnover, poor barrier function, and expression cytokeratin 9, but both clinically scientifically it often regarded just thicker versions “normal” skin. Using the porcine model (which we have found shares many structural molecular similarities with human plantar skin, more so than rodent models), recently that distinctive previously recognized, including a unique gene profile, substantial alterations in tissue calcium distribution store-operated entry response, broad implications key regulator keratinocyte differentiation critical component second messenger signaling. As also an upstream injury signal, developed wound to compare healing response between different types, wounds had inherently slower closure rates, little contraction, sustained abnormalities post-closure architecture. Notably, while keratinocytes are clearly distinct from their non-plantar counterparts, former morphologic other parts body. We posit may constitutively exhibit certain wound-like phenotypes even absence injury, which could lead proclivity towards delayed ulceration becomes most prominently manifested when combined extrinsic stressors, diabetes aging.